Topic

intercurrent-events

Intercurrent-event strategies and operational alignment.

ICH E9(R1) Estimands: Specifying Intercurrent Events Before Endpoint Collection

A methodological guide for clinical development and biostatistics teams to construct ICH E9(R1) estimands, specify intercurrent event strategies, and avoid common missing-data pitfalls.

Aug 2710 minBy Ran Chen

Editorial still life of an unmarked protocol binder, oxblood ribbon, companion folio, and fountain pen on warm parchment