Topic

estimands

Treatment-effect questions expressed through the estimand framework.

ICH E9(R1) Estimands: Specifying Intercurrent Events Before Endpoint Collection

A methodological guide for clinical development and biostatistics teams to construct ICH E9(R1) estimands, specify intercurrent event strategies, and avoid common missing-data pitfalls.

Aug 2710 minBy Ran Chen

Editorial still life of an unmarked protocol binder, oxblood ribbon, companion folio, and fountain pen on warm parchment

Estimands & Statistics

Missing Data vs Intercurrent Events: Estimand-Aligned Sensitivity Analysis

A methodological guide for biostatisticians and clinical trialists to separate intercurrent events from true missing data and pre-specify same-estimand sensitivity analyses.

Aug 279 minBy Ran Chen